Ohio State v. USC - Betting

The line (via VegasInsider) on Ohio State vs. USC is -4.5. How would you bet, and why?

Highlight for how I would bet:

I would definitely take USC to beat the spread.

UPDATE: I considered the typical "3 points" for home-field advantage, but I think that's unwarranted in this case. If I were crafting the line, I would give USC -6.5 or -7.